Assay Detail
Binding
CHEMBL1055318
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Inhibition of human full length cytosolic carbonic anhydrase 3 after 15 mins by stopped-flow CO2 hydration assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.74 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153094 | DECYL SULFAMATE | — | 1 | 6.06 |
| CHEMBL182455 | — | — | 1 | 5.95 |
| CHEMBL171476 | — | — | 1 | 5.92 |
| CHEMBL24261 | OCTYL SULFAMATE | — | 1 | 5.04 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | - |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153094 | DECYL SULFAMATE | Ki | = | 877.0 | nM | 6.06 |
| CHEMBL182455 | — | Ki | = | 1128.0 | nM | 5.95 |
| CHEMBL171476 | — | Ki | = | 1206.0 | nM | 5.92 |
| CHEMBL24261 | OCTYL SULFAMATE | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 200000.0 | nM | - |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 770000.0 | nM | - |