Assay Detail
Functional
CHEMBL1055751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human CCRF-CEM cells after 48 hrs by cell titer-blue assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.72 | 8.25 |
| GI50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 8.25 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.33 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 6.22 |
| CHEMBL727 | THIOGUANINE | 4.0 | 1 | 6.06 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | EC50 | = | 5.614 | nM | 8.25 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 465.4 | nM | 6.33 |
| CHEMBL90555 | VINCRISTINE | EC50 | = | 597.2 | nM | 6.22 |
| CHEMBL727 | THIOGUANINE | EC50 | = | 870.1 | nM | 6.06 |
| CHEMBL65 | CAMPTOTHECIN | GI50 | = | 0.023 | nM | - |