Assay Detail
Binding
CHEMBL1056089
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Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.79 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573032 | — | — | 1 | 5.15 |
| CHEMBL573950 | — | — | 1 | 4.98 |
| CHEMBL573269 | — | — | 1 | 4.90 |
| CHEMBL221206 | — | — | 1 | 4.79 |
| CHEMBL223514 | — | — | 1 | 4.75 |
| CHEMBL427077 | — | — | 1 | 4.73 |
| CHEMBL575027 | — | — | 1 | 4.61 |
| CHEMBL574602 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573032 | — | Ki | = | 7030.0 | nM | 5.15 |
| CHEMBL573950 | — | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL573269 | — | Ki | = | 12700.0 | nM | 4.90 |
| CHEMBL221206 | — | Ki | = | 16300.0 | nM | 4.79 |
| CHEMBL223514 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL427077 | — | Ki | = | 18700.0 | nM | 4.73 |
| CHEMBL575027 | — | Ki | = | 24300.0 | nM | 4.61 |
| CHEMBL574602 | — | Ki | = | 41700.0 | nM | 4.38 |