Assay Detail
Binding
CHEMBL1056199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (CHEMBL2221345) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.13 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368640 | — | — | 1 | 5.23 |
| CHEMBL562810 | MULBERROFURAN W | — | 1 | 5.22 |
| CHEMBL564896 | ALBAFURAN A | — | 1 | 5.20 |
| CHEMBL570526 | KUWANON R | — | 1 | 5.19 |
| CHEMBL204813 | SANGGENON C | — | 1 | 5.08 |
| CHEMBL570475 | KUWANON J | — | 1 | 5.07 |
| CHEMBL525084 | SANGGENON O | — | 1 | 5.06 |
| CHEMBL517247 | MULBERROFURAN D | — | 1 | 5.06 |
| CHEMBL570609 | KUWANON V | — | 1 | 5.02 |
| CHEMBL205924 | MORACIN O | — | 1 | - |
| CHEMBL561971 | MORACIN P | — | 1 | - |
| CHEMBL562169 | MORACIN Q | — | 1 | - |
| CHEMBL512578 | MORACIN M | — | 1 | - |
| CHEMBL563553 | MULBERROFURAN H | — | 1 | - |
| CHEMBL445265 | MULBERROFURAN G | — | 1 | - |
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368640 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL562810 | MULBERROFURAN W | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL564896 | ALBAFURAN A | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL570526 | KUWANON R | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL204813 | SANGGENON C | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL570475 | KUWANON J | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL525084 | SANGGENON O | IC50 | = | 8750.0 | nM | 5.06 |
| CHEMBL517247 | MULBERROFURAN D | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL570609 | KUWANON V | IC50 | = | 9540.0 | nM | 5.02 |
| CHEMBL205924 | MORACIN O | IC50 | > | 30000.0 | nM | - |
| CHEMBL561971 | MORACIN P | IC50 | > | 30000.0 | nM | - |
| CHEMBL562169 | MORACIN Q | IC50 | > | 30000.0 | nM | - |
| CHEMBL512578 | MORACIN M | IC50 | > | 30000.0 | nM | - |
| CHEMBL563553 | MULBERROFURAN H | IC50 | > | 30000.0 | nM | - |
| CHEMBL445265 | MULBERROFURAN G | IC50 | > | 30000.0 | nM | - |
| CHEMBL383824 | ALVESPIMYCIN | IC50 | > | 30000.0 | nM | - |