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Assay Detail

CHEMBL1056419

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT-tetrazolium assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings.
Chen CH, Lin YW, Zhang X, Chou TC, Tsai TJ, Kapuriya N, Kakadiya R, Su TL.
Eur J Med Chem (2009) 44 : 3056 -3059
PubMed 18752869 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.73 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428647 PACLITAXEL 4.0 1 8.96
CHEMBL539428 1 8.89
CHEMBL378694 1 8.38
CHEMBL542011 1 8.22
CHEMBL379854 1 8.17
CHEMBL559235 1 7.85
CHEMBL564839 1 7.77
CHEMBL185119 1 7.70
CHEMBL553412 1 7.68
CHEMBL556418 1 7.25
CHEMBL184802 1 7.07
CHEMBL560979 1 6.41
CHEMBL321473 1 6.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428647 PACLITAXEL IC50 = 1.1 nM 8.96
CHEMBL539428 IC50 = 1.3 nM 8.89
CHEMBL378694 IC50 = 4.2 nM 8.38
CHEMBL542011 IC50 = 6.0 nM 8.22
CHEMBL379854 IC50 = 6.7 nM 8.17
CHEMBL559235 IC50 = 14.2 nM 7.85
CHEMBL564839 IC50 = 17.0 nM 7.77
CHEMBL185119 IC50 = 20.0 nM 7.70
CHEMBL553412 IC50 = 21.0 nM 7.68
CHEMBL556418 IC50 = 56.0 nM 7.25
CHEMBL184802 IC50 = 86.0 nM 7.07
CHEMBL560979 IC50 = 392.0 nM 6.41
CHEMBL321473 IC50 = 753.0 nM 6.12