Assay Detail
Functional
CHEMBL1056792
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Antimalarial activity against Plasmodium yoelii N67
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium yoelii |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 5 | - | - |
| IC50 | 5 | 7.40 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219444 | — | — | 2 | 7.89 |
| CHEMBL218530 | — | — | 2 | 7.85 |
| CHEMBL219967 | — | — | 2 | 7.41 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.97 |
| CHEMBL376236 | — | — | 2 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219444 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL218530 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL219967 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL376236 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL76 | CHLOROQUINE | MIC | = | 390.0 | nM | - |
| CHEMBL218530 | — | MIC | = | 280.0 | nM | - |
| CHEMBL376236 | — | MIC | = | 270.0 | nM | - |
| CHEMBL219444 | — | MIC | = | 260.0 | nM | - |
| CHEMBL219967 | — | MIC | = | 550.0 | nM | - |