Assay Detail
Binding
CHEMBL1056839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MET kinase
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 4 | - | - |
| IC50 | 3 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264938 | GALLOCATECHIN GALLATE | — | 1 | 5.00 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 5.00 |
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 5.00 |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | - |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | - |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | - |
| CHEMBL200715 | (-)-CATECHIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264938 | GALLOCATECHIN GALLATE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL36327 | EPICATECHIN GALLATE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL288114 | GALLIC ACID | Inhibition | - | % | - | |
| CHEMBL47386 | EPIGALLOCATECHIN | Inhibition | - | % | - | |
| CHEMBL583912 | (-)-EPICATECHIN | Inhibition | - | % | - | |
| CHEMBL200715 | (-)-CATECHIN | Inhibition | - | % | - |