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Assay Detail

CHEMBL1056887

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Functional
Antiviral activity against HIV-1 LAI harboring wild type reverse transcriptase infected in human MT4 cells after 5 days by MTT assay
ChEMBL ↗
101
Total Activities
101
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-Iodopyridin-2(1H)-one type anti-HIV agents.
Guillemont J, Benjahad A, Oumouch S, Decrane L, Palandjian P, Vernier D, Queguiner L, Andries K, de Béthune MP, Hertogs K, Grierson DS, Nguyen CH.
J Med Chem (2009) 52 : 7473 -7487
PubMed 19645483 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 101 8.43 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL574163 — — 1 9.20
CHEMBL566750 — — 1 9.20
CHEMBL577247 — — 1 9.10
CHEMBL573185 — — 1 9.10
CHEMBL567623 — — 1 9.00
CHEMBL583934 — — 1 9.00
CHEMBL575689 — — 1 9.00
CHEMBL583736 — — 1 9.00
CHEMBL223228 EFAVIRENZ 4.0 1 9.00
CHEMBL575246 — — 1 8.90
CHEMBL233664 — — 1 8.90
CHEMBL575886 — — 1 8.90
CHEMBL575885 — — 1 8.90
CHEMBL572507 — — 1 8.90
CHEMBL574141 — — 1 8.90
CHEMBL578367 — — 1 8.90
CHEMBL567204 — — 1 8.90
CHEMBL584409 — — 1 8.90
CHEMBL576184 — — 1 8.80
CHEMBL575458 — — 1 8.80
CHEMBL573489 — — 1 8.80
CHEMBL566751 — — 1 8.80
CHEMBL577277 — — 1 8.80
CHEMBL567837 — — 1 8.70
CHEMBL565902 — — 1 8.70
CHEMBL568526 — — 1 8.70
CHEMBL578802 — — 1 8.70
CHEMBL565703 — — 1 8.70
CHEMBL574840 — — 1 8.70
CHEMBL573699 — — 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL574163 — IC50 = 0.63 nM 9.20
CHEMBL566750 — IC50 = 0.63 nM 9.20
CHEMBL577247 — IC50 = 0.79 nM 9.10
CHEMBL573185 — IC50 = 0.79 nM 9.10
CHEMBL567623 — IC50 = 1.0 nM 9.00
CHEMBL583934 — IC50 = 1.0 nM 9.00
CHEMBL575689 — IC50 = 1.0 nM 9.00
CHEMBL583736 — IC50 = 1.0 nM 9.00
CHEMBL223228 EFAVIRENZ IC50 = 1.0 nM 9.00
CHEMBL575885 — IC50 = 1.25 nM 8.90
CHEMBL233664 — IC50 = 1.25 nM 8.90
CHEMBL575886 — IC50 = 1.25 nM 8.90
CHEMBL575246 — IC50 = 1.25 nM 8.90
CHEMBL584409 — IC50 = 1.25 nM 8.90
CHEMBL572507 — IC50 = 1.25 nM 8.90
CHEMBL574141 — IC50 = 1.25 nM 8.90
CHEMBL578367 — IC50 = 1.25 nM 8.90
CHEMBL567204 — IC50 = 1.25 nM 8.90
CHEMBL577277 — IC50 = 1.58 nM 8.80
CHEMBL566751 — IC50 = 1.58 nM 8.80
CHEMBL573489 — IC50 = 1.58 nM 8.80
CHEMBL576184 — IC50 = 1.58 nM 8.80
CHEMBL575458 — IC50 = 1.58 nM 8.80
CHEMBL568526 — IC50 = 1.99 nM 8.70
CHEMBL574374 — IC50 = 1.99 nM 8.70
CHEMBL584160 — IC50 = 1.99 nM 8.70
CHEMBL573699 — IC50 = 1.99 nM 8.70
CHEMBL574840 — IC50 = 1.99 nM 8.70
CHEMBL578802 — IC50 = 1.99 nM 8.70
CHEMBL565902 — IC50 = 1.99 nM 8.70
CHEMBL567837 — IC50 = 1.99 nM 8.70
CHEMBL565703 — IC50 = 1.99 nM 8.70
CHEMBL566761 — IC50 = 2.51 nM 8.60
CHEMBL568278 — IC50 = 2.51 nM 8.60
CHEMBL573732 — IC50 = 2.51 nM 8.60
CHEMBL574164 — IC50 = 2.51 nM 8.60
CHEMBL573720 — IC50 = 2.51 nM 8.60
CHEMBL572798 — IC50 = 3.16 nM 8.50
CHEMBL584137 — IC50 = 3.16 nM 8.50
CHEMBL565477 — IC50 = 3.16 nM 8.50
CHEMBL565702 — IC50 = 3.98 nM 8.40
CHEMBL577276 — IC50 = 3.98 nM 8.40
CHEMBL566556 — IC50 = 3.98 nM 8.40
CHEMBL575464 — IC50 = 3.98 nM 8.40
CHEMBL584571 — IC50 = 3.98 nM 8.40
CHEMBL575683 — IC50 = 3.98 nM 8.40
CHEMBL366692 — IC50 = 3.98 nM 8.40
CHEMBL565712 — IC50 = 5.0 nM 8.30
CHEMBL566555 — IC50 = 5.0 nM 8.30
CHEMBL578558 — IC50 = 5.0 nM 8.30