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Assay Detail

CHEMBL1056891

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Functional
Antiviral activity against HIV1 HXB2 harboring Y188L mutant reverse transcriptase infected in human MT4 cells after 5 days by MTT assay
ChEMBL ↗
101
Total Activities
101
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-Iodopyridin-2(1H)-one type anti-HIV agents.
Guillemont J, Benjahad A, Oumouch S, Decrane L, Palandjian P, Vernier D, Queguiner L, Andries K, de Béthune MP, Hertogs K, Grierson DS, Nguyen CH.
J Med Chem (2009) 52 : 7473 -7487
PubMed 19645483 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 101 6.68 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL567623 — — 1 8.10
CHEMBL577247 — — 1 7.99
CHEMBL584409 — — 1 7.80
CHEMBL574163 — — 1 7.50
CHEMBL574374 — — 1 7.50
CHEMBL583836 — — 1 7.50
CHEMBL568526 — — 1 7.50
CHEMBL565680 — — 1 7.50
CHEMBL567837 — — 1 7.50
CHEMBL578367 — — 1 7.50
CHEMBL567204 — — 1 7.50
CHEMBL566761 — — 1 7.40
CHEMBL578764 — — 1 7.40
CHEMBL572579 — — 1 7.40
CHEMBL565690 — — 1 7.30
CHEMBL233664 — — 1 7.30
CHEMBL575464 — — 1 7.30
CHEMBL584160 — — 1 7.30
CHEMBL572507 — — 1 7.30
CHEMBL568065 — — 1 7.30
CHEMBL565903 — — 1 7.30
CHEMBL573720 — — 1 7.30
CHEMBL565713 — — 1 7.10
CHEMBL568278 — — 1 7.10
CHEMBL566555 — — 1 7.00
CHEMBL578802 — — 1 7.00
CHEMBL583614 — — 1 7.00
CHEMBL565891 — — 1 7.00
CHEMBL573185 — — 1 7.00
CHEMBL575885 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL567623 — IC50 = 7.9 nM 8.10
CHEMBL577247 — IC50 = 10.3 nM 7.99
CHEMBL584409 — IC50 = 15.8 nM 7.80
CHEMBL574163 — IC50 = 31.6 nM 7.50
CHEMBL574374 — IC50 = 31.6 nM 7.50
CHEMBL583836 — IC50 = 31.6 nM 7.50
CHEMBL568526 — IC50 = 31.6 nM 7.50
CHEMBL565680 — IC50 = 31.6 nM 7.50
CHEMBL567837 — IC50 = 31.6 nM 7.50
CHEMBL578367 — IC50 = 31.6 nM 7.50
CHEMBL567204 — IC50 = 31.6 nM 7.50
CHEMBL566761 — IC50 = 39.8 nM 7.40
CHEMBL578764 — IC50 = 39.8 nM 7.40
CHEMBL572579 — IC50 = 39.8 nM 7.40
CHEMBL573720 — IC50 = 50.0 nM 7.30
CHEMBL233664 — IC50 = 50.1 nM 7.30
CHEMBL575464 — IC50 = 50.11 nM 7.30
CHEMBL584160 — IC50 = 50.11 nM 7.30
CHEMBL572507 — IC50 = 50.11 nM 7.30
CHEMBL568065 — IC50 = 50.1 nM 7.30
CHEMBL565903 — IC50 = 50.1 nM 7.30
CHEMBL565690 — IC50 = 50.1 nM 7.30
CHEMBL565713 — IC50 = 79.4 nM 7.10
CHEMBL568278 — IC50 = 79.4 nM 7.10
CHEMBL576184 — IC50 = 100.0 nM 7.00
CHEMBL578802 — IC50 = 100.0 nM 7.00
CHEMBL575885 — IC50 = 100.0 nM 7.00
CHEMBL573185 — IC50 = 100.0 nM 7.00
CHEMBL583614 — IC50 = 100.0 nM 7.00
CHEMBL566555 — IC50 = 100.0 nM 7.00
CHEMBL565891 — IC50 = 100.0 nM 7.00
CHEMBL583934 — IC50 = 125.0 nM 6.90
CHEMBL574834 — IC50 = 125.0 nM 6.90
CHEMBL575246 — IC50 = 125.0 nM 6.90
CHEMBL567205 — IC50 = 125.0 nM 6.90
CHEMBL568496 — IC50 = 125.0 nM 6.90
CHEMBL565689 — IC50 = 125.0 nM 6.90
CHEMBL567838 — IC50 = 125.0 nM 6.90
CHEMBL577276 — IC50 = 125.0 nM 6.90
CHEMBL565702 — IC50 = 125.0 nM 6.90
CHEMBL566547 — IC50 = 125.0 nM 6.90
CHEMBL566750 — IC50 = 125.0 nM 6.90
CHEMBL583839 — IC50 = 158.0 nM 6.80
CHEMBL577277 — IC50 = 158.0 nM 6.80
CHEMBL566751 — IC50 = 158.0 nM 6.80
CHEMBL576627 — IC50 = 158.0 nM 6.80
CHEMBL583425 — IC50 = 158.0 nM 6.80
CHEMBL574164 — IC50 = 158.0 nM 6.80
CHEMBL572798 — IC50 = 158.0 nM 6.80
CHEMBL575886 — IC50 = 158.0 nM 6.80