Assay Detail
Functional
CHEMBL1056894
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 HXB2 harboring 106A mutant reverse transcriptase infected in human MT4 cells after 5 days by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-Iodopyridin-2(1H)-one type anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.10 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL584409 | — | — | 1 | 9.30 |
| CHEMBL574163 | — | — | 1 | 9.22 |
| CHEMBL567204 | — | — | 1 | 8.80 |
| CHEMBL577247 | — | — | 1 | 8.70 |
| CHEMBL568526 | — | — | 1 | 8.43 |
| CHEMBL233664 | — | — | 1 | 8.30 |
| CHEMBL366692 | — | — | 1 | 8.20 |
| CHEMBL578367 | — | — | 1 | 8.10 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.40 |
| CHEMBL338047 | — | — | 1 | 7.40 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL584409 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL574163 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL567204 | — | IC50 | = | 1.58 | nM | 8.80 |
| CHEMBL577247 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL568526 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL233664 | — | IC50 | = | 5.01 | nM | 8.30 |
| CHEMBL366692 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL578367 | — | IC50 | = | 7.94 | nM | 8.10 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL338047 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 5012.0 | nM | 5.30 |