Assay Detail
Functional
CHEMBL1057034
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Antiproliferative activity against human JR8 cells after 72 hrs by trypan blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | JR8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
DNA-targeting pyrroloquinoline-linked butenone and chalcones: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.66 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.96 |
| CHEMBL562185 | — | — | 1 | 5.92 |
| CHEMBL551119 | — | — | 1 | 5.80 |
| CHEMBL551460 | — | — | 1 | 5.68 |
| CHEMBL562882 | — | — | 1 | 5.48 |
| CHEMBL106771 | — | — | 1 | 5.11 |
| CHEMBL572339 | — | — | 1 | - |
| CHEMBL315053 | — | — | 1 | - |
| CHEMBL73639 | BUTENONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123 | ELLIPTECINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL562185 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL551119 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL551460 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL562882 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL106771 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL572339 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL315053 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL73639 | BUTENONE | IC50 | > | 20000.0 | nM | - |