Assay Detail
Binding
CHEMBL1058638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of flag-tagged truncated human mTOR (1360-2549) expressed in HEK293 cells by DELFIA assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.77 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558955 | — | — | 1 | 10.10 |
| CHEMBL538378 | — | — | 1 | 9.70 |
| CHEMBL557963 | — | — | 1 | 9.52 |
| CHEMBL558486 | — | — | 1 | 9.49 |
| CHEMBL556947 | — | — | 1 | 9.47 |
| CHEMBL551440 | — | — | 1 | 9.42 |
| CHEMBL562999 | — | — | 1 | 9.35 |
| CHEMBL563985 | — | — | 1 | 9.34 |
| CHEMBL550972 | — | — | 1 | 9.28 |
| CHEMBL561907 | — | — | 1 | 9.21 |
| CHEMBL540695 | — | — | 1 | 9.08 |
| CHEMBL564404 | — | — | 1 | 9.00 |
| CHEMBL562439 | — | — | 1 | 8.96 |
| CHEMBL551442 | — | — | 1 | 8.85 |
| CHEMBL552532 | — | — | 1 | 8.82 |
| CHEMBL558288 | — | — | 1 | 8.70 |
| CHEMBL562365 | — | — | 1 | 8.68 |
| CHEMBL561708 | — | — | 1 | 8.37 |
| CHEMBL561103 | — | — | 1 | 8.34 |
| CHEMBL561844 | — | — | 1 | 8.15 |
| CHEMBL550286 | — | — | 1 | 8.02 |
| CHEMBL564099 | — | — | 1 | 7.66 |
| CHEMBL562165 | — | — | 1 | 7.34 |
| CHEMBL557895 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558955 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL538378 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL557963 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL558486 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL556947 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL551440 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL562999 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL563985 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL550972 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL561907 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL540695 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL564404 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL562439 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL551442 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL552532 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL558288 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL562365 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL561708 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL561103 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL561844 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL550286 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL564099 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL562165 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL557895 | — | IC50 | = | 2450.0 | nM | 5.61 |