Assay Detail
Functional
CHEMBL1058715
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Antiproliferative activity against human U373 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-373MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.29 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447312 | — | — | 1 | 7.00 |
| CHEMBL502127 | CALACTIN | — | 1 | 6.70 |
| CHEMBL559102 | — | — | 1 | 6.40 |
| CHEMBL555674 | — | — | 1 | 6.40 |
| CHEMBL469426 | — | — | 1 | 6.40 |
| CHEMBL499134 | GHALAKINOSIDE | — | 1 | 6.40 |
| CHEMBL556108 | — | — | 1 | 5.58 |
| CHEMBL558544 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447312 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL502127 | CALACTIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL559102 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL555674 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL469426 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL499134 | GHALAKINOSIDE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL556108 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL558544 | — | IC50 | = | 3400.0 | nM | 5.47 |