Assay Detail
Binding
CHEMBL1058864
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Inhibition of cathepsin K
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Dipeptidyl nitrile inhibitors of Cathepsin L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.41 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560785 | — | — | 1 | 5.90 |
| CHEMBL551060 | — | — | 1 | 5.90 |
| CHEMBL562462 | — | — | 1 | 5.70 |
| CHEMBL565079 | — | — | 1 | 5.60 |
| CHEMBL556421 | — | — | 1 | 5.60 |
| CHEMBL550246 | — | — | 1 | 5.50 |
| CHEMBL564131 | — | — | 1 | 5.50 |
| CHEMBL572332 | — | — | 1 | 5.30 |
| CHEMBL550247 | — | — | 1 | 5.30 |
| CHEMBL559238 | — | — | 1 | 5.30 |
| CHEMBL563886 | — | — | 1 | 5.30 |
| CHEMBL561586 | — | — | 1 | 5.30 |
| CHEMBL561927 | — | — | 1 | 5.20 |
| CHEMBL551059 | — | — | 1 | 5.20 |
| CHEMBL560786 | — | — | 1 | 5.20 |
| CHEMBL551805 | — | — | 1 | 5.20 |
| CHEMBL563522 | — | — | 1 | 5.00 |
| CHEMBL556217 | — | — | 1 | - |
| CHEMBL549365 | — | — | 1 | - |
| CHEMBL552001 | — | — | 1 | - |
| CHEMBL551121 | — | — | 1 | - |
| CHEMBL562325 | — | — | 1 | - |
| CHEMBL561725 | — | — | 1 | - |
| CHEMBL557920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560785 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL551060 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL562462 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL565079 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL556421 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL550246 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL564131 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL572332 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL550247 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL559238 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL563886 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL561586 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL561927 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL551059 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL560786 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL551805 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL563522 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL556217 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL549365 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL552001 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL551121 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL562325 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL561725 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL557920 | — | IC50 | > | 10000.0 | nM | - |