Assay Detail
Binding
CHEMBL1058898
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Inhibition of N-terminal 6xHis-tagged (378-566) catalytic domain of Cdc25B expressed in Escherichia coli after 20 mins by by fluorescent plate reader assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.48 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556292 | — | — | 1 | 5.92 |
| CHEMBL550189 | — | — | 1 | 5.80 |
| CHEMBL556847 | — | — | 1 | 5.77 |
| CHEMBL523844 | — | — | 1 | 5.75 |
| CHEMBL561936 | — | — | 1 | 5.70 |
| CHEMBL562070 | — | — | 1 | 5.68 |
| CHEMBL572127 | — | — | 1 | 5.68 |
| CHEMBL552129 | — | — | 1 | 5.64 |
| CHEMBL557113 | — | — | 1 | 5.64 |
| CHEMBL538199 | — | — | 1 | 5.64 |
| CHEMBL554739 | — | — | 1 | 5.64 |
| CHEMBL560074 | — | — | 1 | 5.60 |
| CHEMBL1401522 | — | — | 1 | 5.58 |
| CHEMBL559679 | — | — | 1 | 5.58 |
| CHEMBL550461 | — | — | 1 | 5.57 |
| CHEMBL552334 | — | — | 1 | 5.55 |
| CHEMBL563983 | — | — | 1 | 5.51 |
| CHEMBL564419 | — | — | 1 | 5.50 |
| CHEMBL551931 | — | — | 1 | 5.48 |
| CHEMBL560991 | — | — | 1 | 5.43 |
| CHEMBL554701 | — | — | 1 | 5.41 |
| CHEMBL557517 | — | — | 1 | 5.38 |
| CHEMBL556499 | — | — | 1 | 5.36 |
| CHEMBL559225 | — | — | 1 | 5.36 |
| CHEMBL549374 | — | — | 1 | 5.35 |
| CHEMBL549785 | — | — | 1 | 5.33 |
| CHEMBL570999 | — | — | 1 | 5.29 |
| CHEMBL562693 | — | — | 1 | 5.28 |
| CHEMBL551673 | — | — | 1 | 5.27 |
| CHEMBL562333 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556292 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL550189 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL556847 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL523844 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL561936 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL562070 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL572127 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL552129 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL557113 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL538199 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL554739 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL560074 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1401522 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL559679 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL550461 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL552334 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL563983 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL564419 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL551931 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL560991 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL554701 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL557517 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL556499 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL559225 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL549374 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL549785 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL570999 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL562693 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL551673 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL562333 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL551872 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL538196 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL429095 | — | IC50 | = | 19200.0 | nM | 4.72 |