Assay Detail
Binding
CHEMBL1059092
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Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.86 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202327 | — | — | 1 | 9.03 |
| CHEMBL560806 | — | — | 1 | 8.93 |
| CHEMBL3215581 | — | — | 1 | 8.76 |
| CHEMBL561343 | — | — | 1 | 8.76 |
| CHEMBL550813 | — | — | 1 | 8.72 |
| CHEMBL563226 | — | — | 1 | 8.70 |
| CHEMBL560884 | — | — | 1 | 8.63 |
| CHEMBL3215789 | — | — | 1 | 8.61 |
| CHEMBL557532 | — | — | 1 | 7.97 |
| CHEMBL3216234 | — | — | 1 | 7.95 |
| CHEMBL563763 | — | — | 1 | 7.91 |
| CHEMBL3216442 | — | — | 1 | 7.78 |
| CHEMBL3215583 | — | — | 1 | 7.69 |
| CHEMBL557259 | — | — | 1 | 7.67 |
| CHEMBL550611 | — | — | 1 | 7.59 |
| CHEMBL557942 | — | — | 1 | 7.50 |
| CHEMBL561948 | — | — | 1 | 7.46 |
| CHEMBL561747 | — | — | 1 | 7.42 |
| CHEMBL550204 | — | — | 1 | 7.41 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 7.19 |
| CHEMBL3217122 | — | — | 1 | 6.54 |
| CHEMBL550266 | — | — | 1 | 6.49 |
| CHEMBL559690 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202327 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL560806 | — | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL3215581 | — | IC50 | = | 1.73 | nM | 8.76 |
| CHEMBL561343 | — | IC50 | = | 1.74 | nM | 8.76 |
| CHEMBL550813 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL563226 | — | IC50 | = | 1.98 | nM | 8.70 |
| CHEMBL560884 | — | IC50 | = | 2.34 | nM | 8.63 |
| CHEMBL3215789 | — | IC50 | = | 2.44 | nM | 8.61 |
| CHEMBL557532 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL3216234 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL563763 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL3216442 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL3215583 | — | IC50 | = | 20.3 | nM | 7.69 |
| CHEMBL557259 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL550611 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL557942 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL561948 | — | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL561747 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL550204 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3217122 | — | IC50 | = | 287.3 | nM | 6.54 |
| CHEMBL550266 | — | IC50 | = | 326.2 | nM | 6.49 |
| CHEMBL559690 | — | IC50 | = | 653.8 | nM | 6.18 |