Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1059151

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to 5HT1A receptor in rat hippocampus
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Hippocampus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands.
Zajdel P, Subra G, Verdie P, Gabzdyl E, Bojarski AJ, Duszyńska B, Martinez J, Pawłowski M.
Bioorg Med Chem Lett (2009) 19 : 4827 -4831
PubMed 19560916 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.79 8.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL497749 1 8.34
CHEMBL204171 1 7.46
CHEMBL557330 1 6.28
CHEMBL563760 1 5.96
CHEMBL564509 1 5.68
CHEMBL558025 1 5.34
CHEMBL550881 1 5.01
CHEMBL559260 1 4.99
CHEMBL550740 1 4.98
CHEMBL557740 1 4.92
CHEMBL561750 1 4.75
CHEMBL282199 1 -
CHEMBL561346 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL497749 Ki = 4.6 nM 8.34
CHEMBL204171 Ki = 35.0 nM 7.46
CHEMBL557330 Ki = 520.0 nM 6.28
CHEMBL563760 Ki = 1098.0 nM 5.96
CHEMBL564509 Ki = 2080.0 nM 5.68
CHEMBL558025 Ki = 4555.0 nM 5.34
CHEMBL550881 Ki = 9860.0 nM 5.01
CHEMBL559260 Ki = 10200.0 nM 4.99
CHEMBL550740 Ki = 10420.0 nM 4.98
CHEMBL557740 Ki = 12050.0 nM 4.92
CHEMBL561750 Ki = 17590.0 nM 4.75
CHEMBL282199 Ki > 10000.0 nM -
CHEMBL561346 Ki > 4000.0 nM -