Assay Detail
Binding
CHEMBL1059705
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Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.12 | 7.14 |
| IC50 | 1 | 4.03 | 4.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.14 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 7.11 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 7.10 |
| CHEMBL560175 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL941 | IMATINIB | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL255863 | NILOTINIB | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL560175 | — | IC50 | = | 93100.0 | nM | 4.03 |