Assay Detail
Binding
CHEMBL1059967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.17 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 6.06 |
| CHEMBL550069 | — | — | 1 | 5.53 |
| CHEMBL556929 | — | — | 1 | 5.36 |
| CHEMBL558230 | — | — | 1 | 5.18 |
| CHEMBL559056 | — | — | 1 | 5.00 |
| CHEMBL552145 | — | — | 1 | 4.53 |
| CHEMBL274990 | SC-58125 | — | 1 | 4.50 |
| CHEMBL559952 | — | — | 1 | - |
| CHEMBL554903 | — | — | 1 | - |
| CHEMBL564962 | — | — | 1 | - |
| CHEMBL556724 | — | — | 1 | - |
| CHEMBL559422 | — | — | 1 | - |
| CHEMBL562768 | — | — | 1 | - |
| CHEMBL563455 | — | — | 1 | - |
| CHEMBL561888 | — | — | 1 | - |
| CHEMBL551749 | — | — | 1 | - |
| CHEMBL549457 | — | — | 1 | - |
| CHEMBL564087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL550069 | — | IC50 | = | 2969.0 | nM | 5.53 |
| CHEMBL556929 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL558230 | — | IC50 | = | 6541.0 | nM | 5.18 |
| CHEMBL559056 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL552145 | — | IC50 | = | 29371.0 | nM | 4.53 |
| CHEMBL274990 | SC-58125 | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL559952 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL554903 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL564962 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL556724 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL559422 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL562768 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL563455 | — | IC50 | > | 34000.0 | nM | - |
| CHEMBL561888 | — | IC50 | > | 52124.0 | nM | - |
| CHEMBL551749 | — | IC50 | - | — | - | |
| CHEMBL549457 | — | IC50 | - | — | - | |
| CHEMBL564087 | — | IC50 | - | — | - |