Assay Detail
Binding
CHEMBL1060018
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Inhibition of human recombinant ACE by fluorimetry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.73 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 9.92 |
| CHEMBL540674 | — | — | 1 | 6.80 |
| CHEMBL560409 | — | — | 1 | 6.55 |
| CHEMBL551145 | — | — | 1 | 6.52 |
| CHEMBL551622 | — | — | 1 | 6.40 |
| CHEMBL560685 | — | — | 1 | 6.08 |
| CHEMBL558146 | — | — | 1 | 6.00 |
| CHEMBL367174 | — | — | 1 | 5.55 |
| CHEMBL173287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL540674 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL560409 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL551145 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL551622 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL560685 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL558146 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL367174 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL173287 | — | IC50 | > | 10000.0 | nM | - |