Assay Detail
Binding
CHEMBL1060370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.92 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423294 | CYCLAZOSIN | — | 1 | 9.49 |
| CHEMBL564481 | CYCLODOXAZOSIN | — | 1 | 9.38 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 9.09 |
| CHEMBL561851 | — | — | 1 | 9.03 |
| CHEMBL558890 | — | — | 1 | 8.85 |
| CHEMBL549764 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423294 | CYCLAZOSIN | Ki | = | 0.3236 | nM | 9.49 |
| CHEMBL564481 | CYCLODOXAZOSIN | Ki | = | 0.4169 | nM | 9.38 |
| CHEMBL707 | DOXAZOSIN | Ki | = | 0.8128 | nM | 9.09 |
| CHEMBL561851 | — | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL558890 | — | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL549764 | — | Ki | = | 22.39 | nM | 7.65 |