Assay Detail
Functional
CHEMBL1060377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human LNCAP cells after 72 hrs by CellTitter-Glo luminescent cell viability assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.29 | 6.24 |
| EC50 | 1 | 5.85 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL564481 | CYCLODOXAZOSIN | — | 2 | 6.24 |
| CHEMBL561851 | — | — | 1 | 5.34 |
| CHEMBL549764 | — | — | 1 | 5.01 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL564481 | CYCLODOXAZOSIN | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL564481 | CYCLODOXAZOSIN | EC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL561851 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL549764 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL707 | DOXAZOSIN | IC50 | = | 28110.0 | nM | 4.55 |