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Target Snapshot

CHEMBL612518 Target Snapshot

LNCaP · CELL-LINE · Homo sapiens

5,611Compounds
1,865Assays
49Approved Drugs
4,381.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats LNCaP as ChEMBL target CHEMBL612518. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
LNCaP
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL612518
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether LNCaP still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLNCaP
UniProt AccessionN/A

LNCaP

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as LNCaP.

Review nameLNCaP
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

49
Approved
19
Phase III
25
Phase II
9
Phase I
Assay Mix

Activity Type Distribution

IC504,181.0
EC50200.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5274822 10.0 IC50 0.1 Preclinical
CHEMBL5205159 10.0 IC50 0.1 Preclinical
CHEMBL5203778 10.0 IC50 0.1 Preclinical
CHEMBL5183992 10.0 IC50 0.1 Preclinical
CHEMBL92 9.7 IC50 0.2 Approved
CHEMBL4740749 9.6 IC50 0.25 Preclinical
CHEMBL5191359 9.52 IC50 0.3 Preclinical
CHEMBL5173006 9.52 IC50 0.3 Preclinical
CHEMBL5180617 9.4 IC50 0.4 Preclinical
CHEMBL1201182 9.3 IC50 0.5 Approved
Distribution

pChEMBL Value Distribution

728
5.0
544
5.5
382
6.0
249
6.5
180
7.0
152
7.5
62
8.0
43
8.5
39
9.0
5
9.5
pChEMBL
Approved Drugs

Approved Drugs

CAPIVASERTIB
CHEMBL2325741
Approved 2023
PACRITINIB
CHEMBL2035187
Approved 2022
APALUTAMIDE
CHEMBL3183409
Approved 2018
ABEMACICLIB
CHEMBL3301610
Approved 2017
ENZALUTAMIDE
CHEMBL1082407
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
VORINOSTAT
CHEMBL98
Approved 2006
FULVESTRANT
CHEMBL1358
Approved 2002
IRINOTECAN
CHEMBL481
Approved 1996
GEMCITABINE
CHEMBL888
Approved 1996
TOPOTECAN
CHEMBL84
Approved 1996
BICALUTAMIDE
CHEMBL409
Approved 1995
DOCETAXEL ANHYDROUS
CHEMBL92
Approved 1995
PACLITAXEL
CHEMBL428647
Approved 1992
PODOFILOX
CHEMBL61
Approved 1990
FLUTAMIDE
CHEMBL806
Approved 1989
NICLOSAMIDE
CHEMBL1448
Approved 1982
DAUNORUBICIN
CHEMBL178
Approved 1979
DOXORUBICIN
CHEMBL53463
Approved 1974
TRETINOIN
CHEMBL38
Approved 1971
FLOXURIDINE
CHEMBL917
Approved 1970
VINBLASTINE
CHEMBL159
Approved 1965
VINBLASTINE SULFATE
CHEMBL378544
Approved 1965
VINCRISTINE SULFATE
CHEMBL501867
Approved 1963
FLUOROURACIL
CHEMBL185
Approved 1962
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

1,868
Total Assays
3,148
Tested Compounds
4
Assay Types
Functional — 1,792 assays, 3,148 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,655 3,148 5.7
organism-based format 137 0
ADME — 67 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 53 12 5.8
organism-based format 14 0
Toxicity — 6 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 2 5.4
Unassigned — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine