Assay Detail
Binding
CHEMBL1060393
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.95 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31354 | WAY-100,635 | — | 1 | 9.05 |
| CHEMBL551909 | — | — | 1 | 8.82 |
| CHEMBL564148 | — | — | 1 | 8.70 |
| CHEMBL560170 | — | — | 1 | 8.55 |
| CHEMBL562248 | — | — | 1 | 8.52 |
| CHEMBL551964 | — | — | 1 | 8.43 |
| CHEMBL551107 | — | — | 1 | 8.26 |
| CHEMBL551304 | — | — | 1 | 8.17 |
| CHEMBL559778 | — | — | 1 | 8.14 |
| CHEMBL550700 | — | — | 1 | 7.76 |
| CHEMBL556474 | — | — | 1 | 7.70 |
| CHEMBL550169 | — | — | 1 | 7.48 |
| CHEMBL550576 | — | — | 1 | 7.33 |
| CHEMBL565234 | — | — | 1 | 6.78 |
| CHEMBL551105 | — | — | 1 | 6.76 |
| CHEMBL559579 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31354 | WAY-100,635 | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL551909 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL564148 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL560170 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL562248 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL551964 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL551107 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL551304 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL559778 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL550700 | — | Ki | = | 17.2 | nM | 7.76 |
| CHEMBL556474 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL550169 | — | Ki | = | 32.9 | nM | 7.48 |
| CHEMBL550576 | — | Ki | = | 47.3 | nM | 7.33 |
| CHEMBL565234 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL551105 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL559579 | — | Ki | = | 214.1 | nM | 6.67 |