Assay Detail
Binding
CHEMBL1062472
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Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavage
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design of selective Cathepsin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.99 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555122 | — | — | 1 | 8.90 |
| CHEMBL557455 | — | — | 1 | 8.70 |
| CHEMBL554065 | — | — | 1 | 8.40 |
| CHEMBL550872 | — | — | 1 | 8.30 |
| CHEMBL549378 | — | — | 1 | 8.30 |
| CHEMBL549791 | — | — | 1 | 8.20 |
| CHEMBL565079 | — | — | 1 | 7.90 |
| CHEMBL564131 | — | — | 1 | 7.90 |
| CHEMBL563471 | — | — | 1 | 7.80 |
| CHEMBL562915 | — | — | 1 | 7.80 |
| CHEMBL562844 | — | — | 1 | 6.90 |
| CHEMBL559880 | — | — | 1 | 6.70 |
| CHEMBL550246 | — | — | 1 | 6.60 |
| CHEMBL564626 | — | — | 1 | 6.30 |
| CHEMBL560736 | — | — | 1 | 6.30 |
| CHEMBL561802 | — | — | 1 | 6.10 |
| CHEMBL556436 | — | — | 1 | 5.90 |
| CHEMBL556504 | — | — | 1 | 5.80 |
| CHEMBL563056 | — | — | 1 | 5.80 |
| CHEMBL550059 | — | — | 1 | 5.70 |
| CHEMBL556434 | — | — | 1 | 5.50 |
| CHEMBL559248 | — | — | 1 | 5.50 |
| CHEMBL551533 | — | — | 1 | 5.40 |
| CHEMBL563517 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555122 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL557455 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL554065 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL550872 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL549378 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL549791 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL565079 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL564131 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL563471 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL562915 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL562844 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL559880 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL550246 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL564626 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL560736 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL561802 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL556436 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL556504 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL563056 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL550059 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL556434 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL559248 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL551533 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL563517 | — | IC50 | > | 7943.28 | nM | - |