Assay Detail
Binding
CHEMBL1062475
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Inhibition of cathepsin K assessed as inhibition of fluorogenic substrate cleavage
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design of selective Cathepsin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.22 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550872 | — | — | 1 | 7.20 |
| CHEMBL549791 | — | — | 1 | 7.00 |
| CHEMBL554065 | — | — | 1 | 6.90 |
| CHEMBL549378 | — | — | 1 | 6.90 |
| CHEMBL562915 | — | — | 1 | 6.90 |
| CHEMBL555122 | — | — | 1 | 6.80 |
| CHEMBL559880 | — | — | 1 | 6.20 |
| CHEMBL557455 | — | — | 1 | 6.00 |
| CHEMBL564626 | — | — | 1 | 5.90 |
| CHEMBL565079 | — | — | 1 | 5.60 |
| CHEMBL550246 | — | — | 1 | 5.50 |
| CHEMBL564131 | — | — | 1 | 5.50 |
| CHEMBL562844 | — | — | 1 | 5.50 |
| CHEMBL563471 | — | — | 1 | 5.20 |
| CHEMBL563056 | — | — | 1 | - |
| CHEMBL556434 | — | — | 1 | - |
| CHEMBL556436 | — | — | 1 | - |
| CHEMBL563517 | — | — | 1 | - |
| CHEMBL561802 | — | — | 1 | - |
| CHEMBL551533 | — | — | 1 | - |
| CHEMBL550059 | — | — | 1 | - |
| CHEMBL556504 | — | — | 1 | - |
| CHEMBL559248 | — | — | 1 | - |
| CHEMBL560736 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550872 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL549791 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL554065 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL549378 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL562915 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL555122 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL559880 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL557455 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL564626 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL565079 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL550246 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL564131 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL562844 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL563471 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL563056 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL556434 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL556436 | — | IC50 | > | 6309.57 | nM | - |
| CHEMBL563517 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL561802 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL551533 | — | IC50 | > | 7943.28 | nM | - |
| CHEMBL550059 | — | IC50 | > | 7943.28 | nM | - |
| CHEMBL556504 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL559248 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL560736 | — | IC50 | > | 10000.0 | nM | - |