Assay Detail
Binding
CHEMBL1062525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Diprenorphine from rat kappa opioid receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.40 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216640 | — | — | 1 | 9.24 |
| CHEMBL550968 | — | — | 1 | 9.08 |
| CHEMBL538705 | — | — | 1 | 8.86 |
| CHEMBL555959 | — | — | 1 | 8.61 |
| CHEMBL554841 | — | — | 1 | 8.02 |
| CHEMBL564095 | — | — | 1 | 7.96 |
| CHEMBL553657 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216640 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL550968 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL538705 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL555959 | — | Ki | = | 2.46 | nM | 8.61 |
| CHEMBL554841 | — | Ki | = | 9.46 | nM | 8.02 |
| CHEMBL564095 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL553657 | — | Ki | = | 87.2 | nM | 7.06 |