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Assay Detail

CHEMBL1063233

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Immunosuppressive activity in splenocytes assessed as inhibition of mixed lymphocyte reaction
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type Splenocyte
Confidence 1 — Organism
Curated By Autocuration

Target

Splenocyte (CHEMBL612422)
Type CELL-LINE
Organism Mus musculus

Publication

Design, synthesis and identification of novel colchicine-derived immunosuppressant.
Chang DJ, Yoon EY, Lee GB, Kim SO, Kim WJ, Kim YM, Jung JW, An H, Suh YG.
Bioorg Med Chem Lett (2009) 19 : 4416 -4420
PubMed 19502058 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 7.29 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL561464 1 8.40
CHEMBL564976 1 8.40
CHEMBL563501 1 8.10
CHEMBL541011 1 8.05
CHEMBL557741 1 7.82
CHEMBL551596 1 7.51
CHEMBL539190 1 7.31
CHEMBL560784 1 7.30
CHEMBL537944 1 7.27
CHEMBL552537 1 7.26
CHEMBL537943 1 7.24
CHEMBL564848 1 7.21
CHEMBL562721 1 7.19
CHEMBL558245 1 7.17
CHEMBL563859 1 7.17
CHEMBL551689 1 7.14
CHEMBL556579 1 7.11
CHEMBL562723 1 7.07
CHEMBL562065 1 7.05
CHEMBL550922 1 7.05
CHEMBL556840 1 6.99
CHEMBL539693 1 6.54
CHEMBL559345 1 6.36
CHEMBL541009 1 6.16
CHEMBL553195 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL561464 IC50 = 4.0 nM 8.40
CHEMBL564976 IC50 = 4.0 nM 8.40
CHEMBL563501 IC50 = 8.0 nM 8.10
CHEMBL541011 IC50 = 9.0 nM 8.05
CHEMBL557741 IC50 = 15.0 nM 7.82
CHEMBL551596 IC50 = 31.0 nM 7.51
CHEMBL539190 IC50 = 49.0 nM 7.31
CHEMBL560784 IC50 = 50.0 nM 7.30
CHEMBL537944 IC50 = 54.0 nM 7.27
CHEMBL552537 IC50 = 55.0 nM 7.26
CHEMBL537943 IC50 = 58.0 nM 7.24
CHEMBL564848 IC50 = 61.0 nM 7.21
CHEMBL562721 IC50 = 65.0 nM 7.19
CHEMBL558245 IC50 = 68.0 nM 7.17
CHEMBL563859 IC50 = 68.0 nM 7.17
CHEMBL551689 IC50 = 73.0 nM 7.14
CHEMBL556579 IC50 = 78.0 nM 7.11
CHEMBL562723 IC50 = 85.0 nM 7.07
CHEMBL562065 IC50 = 89.0 nM 7.05
CHEMBL550922 IC50 = 89.0 nM 7.05
CHEMBL556840 IC50 = 103.0 nM 6.99
CHEMBL539693 IC50 = 290.0 nM 6.54
CHEMBL559345 IC50 = 434.0 nM 6.36
CHEMBL541009 IC50 = 700.0 nM 6.16
CHEMBL553195 IC50 - -