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Assay Detail

CHEMBL1063928

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Functional
Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction preincubated for 30 mins before phenylephrine addition
ChEMBL ↗
62
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Aorta
Confidence 1 — Organism
Curated By Autocuration

Target

Aorta (CHEMBL613606) ↗
Type TISSUE
Organism Rattus norvegicus

Publication

(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins.
Lazzarato L, Donnola M, Rolando B, Chegaev K, Marini E, Cena C, Di Stilo A, Fruttero R, Biondi S, Ongini E, Gasco A.
J Med Chem (2009) 52 : 5058 -5068
PubMed 20560642 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 31 6.12 7.77
Activity 31 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL550084 — — 2 7.77
CHEMBL550085 — — 2 7.39
CHEMBL561102 — — 2 7.28
CHEMBL572585 — — 2 7.12
CHEMBL564376 — — 2 7.00
CHEMBL557896 — — 2 6.85
CHEMBL560900 — — 2 6.85
CHEMBL564319 — — 2 6.82
CHEMBL563807 — — 2 6.57
CHEMBL540218 — — 2 6.57
CHEMBL487821 — — 2 6.55
CHEMBL486462 — — 2 6.48
CHEMBL551157 — — 2 6.44
CHEMBL557484 — — 2 6.41
CHEMBL551441 — — 2 6.33
CHEMBL538375 — — 2 6.29
CHEMBL562229 — — 2 6.28
CHEMBL561563 — — 2 6.21
CHEMBL553163 — — 2 6.09
CHEMBL562226 — — 2 5.92
CHEMBL561241 — — 2 5.80
CHEMBL560704 — — 2 5.42
CHEMBL562713 — — 2 5.40
CHEMBL549881 — — 2 5.24
CHEMBL558094 — — 2 5.22
CHEMBL550632 — — 2 5.17
CHEMBL541439 — — 2 5.08
CHEMBL553889 — — 2 4.92
CHEMBL557391 — — 2 4.70
CHEMBL539444 — — 2 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL550084 — EC50 = 17.0 nM 7.77
CHEMBL550085 — EC50 = 41.0 nM 7.39
CHEMBL561102 — EC50 = 52.0 nM 7.28
CHEMBL572585 — EC50 = 75.0 nM 7.12
CHEMBL564376 — EC50 = 100.0 nM 7.00
CHEMBL560900 — EC50 = 140.0 nM 6.85
CHEMBL557896 — EC50 = 140.0 nM 6.85
CHEMBL564319 — EC50 = 150.0 nM 6.82
CHEMBL540218 — EC50 = 270.0 nM 6.57
CHEMBL563807 — EC50 = 270.0 nM 6.57
CHEMBL487821 — EC50 = 280.0 nM 6.55
CHEMBL486462 — EC50 = 330.0 nM 6.48
CHEMBL551157 — EC50 = 360.0 nM 6.44
CHEMBL557484 — EC50 = 390.0 nM 6.41
CHEMBL551441 — EC50 = 470.0 nM 6.33
CHEMBL538375 — EC50 = 510.0 nM 6.29
CHEMBL562229 — EC50 = 520.0 nM 6.28
CHEMBL561563 — EC50 = 620.0 nM 6.21
CHEMBL553163 — EC50 = 820.0 nM 6.09
CHEMBL562226 — EC50 = 1200.0 nM 5.92
CHEMBL561241 — EC50 = 1600.0 nM 5.80
CHEMBL560704 — EC50 = 3800.0 nM 5.42
CHEMBL562713 — EC50 = 4000.0 nM 5.40
CHEMBL549881 — EC50 = 5800.0 nM 5.24
CHEMBL558094 — EC50 = 6000.0 nM 5.22
CHEMBL550632 — EC50 = 6800.0 nM 5.17
CHEMBL541439 — EC50 = 8300.0 nM 5.08
CHEMBL553889 — EC50 = 12000.0 nM 4.92
CHEMBL564335 — EC50 = 20000.0 nM 4.70
CHEMBL539444 — EC50 = 20000.0 nM 4.70
CHEMBL557391 — EC50 = 20000.0 nM 4.70
CHEMBL560900 — Activity - — -
CHEMBL561563 — Activity - — -
CHEMBL550084 — Activity - — -
CHEMBL487821 — Activity - — -
CHEMBL553163 — Activity - — -
CHEMBL553889 — Activity - — -
CHEMBL551157 — Activity - — -
CHEMBL564335 — Activity - — -
CHEMBL551441 — Activity - — -
CHEMBL558094 — Activity - — -
CHEMBL564376 — Activity - — -
CHEMBL563807 — Activity - — -
CHEMBL564319 — Activity - — -
CHEMBL540218 — Activity - — -
CHEMBL561102 — Activity - — -
CHEMBL486462 — Activity - — -
CHEMBL572585 — Activity - — -
CHEMBL538375 — Activity - — -
CHEMBL550085 — Activity - — -