Assay Detail
Functional
CHEMBL1063929
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Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction preincubated for 30 mins before phenylephrine addition in presence of 1 uM 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.22 | 4.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540218 | — | — | 1 | 4.28 |
| CHEMBL563807 | — | — | 1 | 4.25 |
| CHEMBL561563 | — | — | 1 | 4.18 |
| CHEMBL487821 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540218 | — | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL563807 | — | EC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL561563 | — | EC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL487821 | — | EC50 | = | 67000.0 | nM | 4.17 |