Assay Detail
Functional
CHEMBL1064072
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Cytotoxicity against human MCF7/ADR cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimultidrug resistance evaluation of icariin and its derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.31 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562255 | — | — | 1 | 4.68 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.60 |
| CHEMBL498485 | ICARITIN | 3.0 | 1 | 4.28 |
| CHEMBL558896 | — | — | 1 | 4.26 |
| CHEMBL558499 | — | — | 1 | 4.22 |
| CHEMBL550300 | — | — | 1 | 4.09 |
| CHEMBL563542 | — | — | 1 | 4.04 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | - |
| CHEMBL558897 | — | — | 1 | - |
| CHEMBL497654 | — | — | 1 | - |
| CHEMBL560116 | — | — | 1 | - |
| CHEMBL553204 | ICARIIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562255 | — | IC50 | = | 20930.0 | nM | 4.68 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 25280.0 | nM | 4.60 |
| CHEMBL498485 | ICARITIN | IC50 | = | 52090.0 | nM | 4.28 |
| CHEMBL558896 | — | IC50 | = | 54950.0 | nM | 4.26 |
| CHEMBL558499 | — | IC50 | = | 60780.0 | nM | 4.22 |
| CHEMBL550300 | — | IC50 | = | 80780.0 | nM | 4.09 |
| CHEMBL563542 | — | IC50 | = | 92130.0 | nM | 4.04 |
| CHEMBL6966 | VERAPAMIL | IC50 | > | 100000.0 | nM | - |
| CHEMBL558897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL497654 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL560116 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL553204 | ICARIIN | IC50 | > | 100000.0 | nM | - |