Assay Detail
Functional
CHEMBL1064650
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Cytotoxicity against human CEM cells after 2 days
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.53 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.72 |
| CHEMBL596245 | — | — | 1 | 8.55 |
| CHEMBL592982 | — | — | 1 | 7.70 |
| CHEMBL608716 | — | — | 1 | 7.16 |
| CHEMBL492212 | — | — | 1 | 7.11 |
| CHEMBL522420 | — | — | 1 | 7.06 |
| CHEMBL595360 | — | — | 1 | 7.00 |
| CHEMBL595788 | — | — | 1 | 6.66 |
| CHEMBL593009 | — | — | 1 | 6.40 |
| CHEMBL594158 | — | — | 1 | 6.37 |
| CHEMBL596488 | — | — | 1 | 6.31 |
| CHEMBL603631 | — | — | 1 | 6.06 |
| CHEMBL611640 | — | — | 1 | 5.82 |
| CHEMBL594406 | — | — | 1 | 5.72 |
| CHEMBL596487 | — | — | 1 | 5.70 |
| CHEMBL606625 | — | — | 1 | 5.62 |
| CHEMBL612136 | — | — | 1 | 5.57 |
| CHEMBL595787 | — | — | 1 | 5.37 |
| CHEMBL595574 | — | — | 1 | 5.14 |
| CHEMBL593948 | — | — | 1 | - |
| CHEMBL594405 | — | — | 1 | - |
| CHEMBL593947 | — | — | 1 | - |
| CHEMBL594632 | — | — | 1 | - |
| CHEMBL596486 | — | — | 1 | - |
| CHEMBL609017 | — | — | 1 | - |
| CHEMBL596464 | — | — | 1 | - |
| CHEMBL596465 | — | — | 1 | - |
| CHEMBL594157 | — | — | 1 | - |
| CHEMBL595575 | — | — | 1 | - |
| CHEMBL606248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL596245 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL592982 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL608716 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL492212 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL522420 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL595360 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL595788 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL593009 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL594158 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL596488 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL603631 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL611640 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL594406 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL596487 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL606625 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL612136 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL595787 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL595574 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL593948 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL594405 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL593947 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL594632 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL596486 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL609017 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL596464 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL596465 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL594157 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL595575 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL606248 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL593949 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL594407 | — | IC50 | > | 10000.0 | nM | - |