Assay Detail
ADMET
CHEMBL1064692
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Cytotoxicity against BAEC
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Bos taurus |
| Cell Type | BAEC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of epothilone A dimeric compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.58 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329993 | EPOTHILONE A | — | 1 | 9.15 |
| CHEMBL594876 | — | — | 1 | 7.70 |
| CHEMBL595070 | — | — | 1 | 7.54 |
| CHEMBL595072 | — | — | 1 | 7.41 |
| CHEMBL594716 | — | — | 1 | 7.40 |
| CHEMBL595071 | — | — | 1 | 6.96 |
| CHEMBL595020 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329993 | EPOTHILONE A | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL594876 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL595070 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL595072 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL594716 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL595071 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL595020 | — | IC50 | = | 133.0 | nM | 6.88 |