Assay Detail
Functional
CHEMBL1064779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 LAI in human CEM-SS cells assessed as RT activity after 5 days by single passage assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
5-Modified-2'-dU and 2'-dC as mutagenic anti HIV-1 proliferation agents: synthesis and activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.92 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.62 |
| CHEMBL597779 | — | — | 1 | 4.62 |
| CHEMBL376876 | — | — | 1 | 4.52 |
| CHEMBL599827 | — | — | 1 | - |
| CHEMBL598602 | — | — | 1 | - |
| CHEMBL223557 | — | — | 1 | - |
| CHEMBL597778 | — | — | 1 | - |
| CHEMBL607569 | — | — | 1 | - |
| CHEMBL597780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL597779 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL376876 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL599827 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL598602 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL223557 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL597778 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL607569 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL597780 | — | IC50 | > | 200000.0 | nM | - |