Assay Detail
Functional
CHEMBL1065268
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Antiinflammatory activity against LPS-stimulated TNFalpha production in human monocytes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Monocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.72 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL591797 | — | — | 1 | 7.26 |
| CHEMBL592030 | — | — | 1 | 7.07 |
| CHEMBL590109 | — | — | 1 | 6.55 |
| CHEMBL595933 | — | — | 1 | 6.00 |
| CHEMBL596588 | — | — | 1 | - |
| CHEMBL594090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL591797 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL592030 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL590109 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL595933 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL596588 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL594090 | — | IC50 | > | 25000.0 | nM | - |