Assay Detail
Binding
CHEMBL1065424
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Inhibition of Torpedo california AChE by Ellman's method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.78 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606348 | — | — | 1 | 10.70 |
| CHEMBL594870 | — | — | 1 | 10.61 |
| CHEMBL596236 | — | — | 1 | 10.39 |
| CHEMBL593933 | — | — | 1 | 10.35 |
| CHEMBL606372 | — | — | 1 | 9.92 |
| CHEMBL605303 | — | — | 1 | 9.07 |
| CHEMBL594187 | — | — | 1 | 8.79 |
| CHEMBL595114 | — | — | 1 | 8.74 |
| CHEMBL604478 | — | — | 1 | 8.17 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.94 |
| CHEMBL606538 | — | — | 1 | 7.86 |
| CHEMBL596457 | — | — | 1 | 7.74 |
| CHEMBL338975 | PHYSOSTIGMINE SALICYLATE | -1.0 | 1 | 7.67 |
| CHEMBL595115 | — | — | 1 | 7.63 |
| CHEMBL594186 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606348 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL594870 | — | IC50 | = | 0.0246 | nM | 10.61 |
| CHEMBL596236 | — | IC50 | = | 0.0412 | nM | 10.39 |
| CHEMBL593933 | — | IC50 | = | 0.0446 | nM | 10.35 |
| CHEMBL606372 | — | IC50 | = | 0.121 | nM | 9.92 |
| CHEMBL605303 | — | IC50 | = | 0.842 | nM | 9.07 |
| CHEMBL594187 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL595114 | — | IC50 | = | 1.81 | nM | 8.74 |
| CHEMBL604478 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL606538 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL596457 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL338975 | PHYSOSTIGMINE SALICYLATE | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL595115 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL594186 | — | IC50 | = | 796.0 | nM | 6.10 |