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Target Snapshot

CHEMBL4780 Target Snapshot

Acetylcholinesterase · SINGLE PROTEIN · Torpedo californica

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395Compounds
91Assays
13Approved Drugs
500.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P04058. Use UniProt P04058 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P04058 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Acetylcholinesterase as ChEMBL target CHEMBL4780, mapped to UniProt P04058. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Acetylcholinesterase
SINGLE PROTEIN · Torpedo californica
As of 2026-09-13
ChEMBL target ID
CHEMBL4780
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P04058
Acetylcholinesterase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Acetylcholinesterase is the right protein anchor across sources, using UniProt P04058 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAcetylcholinesterase
Target TypeSINGLE PROTEIN
OrganismTorpedo californica
UniProtP04058
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAcetylcholinesterase
UniProt AccessionP04058
Component TypeProtein
Sequence Length586 aa

Acetylcholinesterase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Acetylcholinesterase, mapped to UniProt P04058. Sequence length is 586 aa.

Mapped IDP04058
Review nameAcetylcholinesterase
OrganismTorpedo californica
Clinical Profile

Clinical Phase Distribution

13
Approved
1
Phase III
3
Phase II
Assay Mix

Activity Type Distribution

IC50436.0
KI60.0
KD4.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL525622 10.82 Ki 0.015 Preclinical
CHEMBL606348 10.7 IC50 0.02 Preclinical
CHEMBL594870 10.61 IC50 0.0246 Preclinical
CHEMBL596236 10.39 IC50 0.0412 Preclinical
CHEMBL593933 10.35 IC50 0.0446 Preclinical
CHEMBL3221007 10.35 IC50 0.045 Preclinical
CHEMBL117651 10.11 Ki 0.077 Preclinical
CHEMBL606372 9.92 IC50 0.121 Preclinical
CHEMBL3221005 9.89 IC50 0.129 Preclinical
CHEMBL208599 9.89 Ki 0.13 Preclinical
Distribution

pChEMBL Value Distribution

57
5.0
32
5.5
28
6.0
34
6.5
49
7.0
62
7.5
40
8.0
26
8.5
9
9.0
4
9.5
pChEMBL
Approved Drugs

Approved Drugs

NEOSTIGMINE
CHEMBL278020
Approved 2013
Properties Compare Identifier
GALANTAMINE
CHEMBL659
Approved 2001
Properties Compare Identifier
DONEPEZIL HYDROCHLORIDE
CHEMBL1678
Approved 1996
Properties Compare Identifier
DONEPEZIL
CHEMBL502
Approved 1996
Properties Compare Identifier
IRINOTECAN
CHEMBL481
Approved 1996
Properties Compare Identifier
TACRINE
CHEMBL95
Approved 1993
Properties Compare Identifier
PYRIDOSTIGMINE
CHEMBL1115
Approved 1955
Properties Compare Identifier
Assay Landscape

Assay Landscape

91
Total Assays
331
Tested Compounds
2
Assay Types
Binding — 89 assays, 331 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 89 331 6.8
ADME — 2 assays, 23 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 23 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine