Compound Detail
CHEMBL3221005
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Basic Information
| ChEMBL ID | CHEMBL3221005 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DKUSVKBLJWMOFH-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
520.7
MW (Da)
7.88
ALogP
4
HBA
3
HBD
66.0
PSA (Ų)
0.18
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acetylcholinesterase CHEMBL4780 | IC50 | 9.89 | 9.27 | 0.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | IC50 | = | 0.129 | nM | 9.89 | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as subst... | - |
| Acetylcholinesterase | IC50 | = | 2.24 | nM | 8.65 | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as subst... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C0MD00256A | Acetylcholinesterase | 2 |
Data from ChEMBL 36 via Core Engine