Assay Detail
Binding
CHEMBL3222359
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Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 7.46 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3221566 | — | — | 1 | 9.38 |
| CHEMBL2393227 | — | — | 1 | 9.30 |
| CHEMBL2393229 | — | — | 1 | 9.11 |
| CHEMBL2393109 | — | — | 1 | 8.94 |
| CHEMBL3221006 | — | — | 1 | 8.86 |
| CHEMBL3221008 | — | — | 1 | 8.81 |
| CHEMBL3221292 | — | — | 1 | 8.78 |
| CHEMBL3221005 | — | — | 1 | 8.65 |
| CHEMBL2393111 | — | — | 1 | 8.53 |
| CHEMBL3221286 | — | — | 1 | 8.48 |
| CHEMBL3221285 | — | — | 1 | 8.44 |
| CHEMBL278020 | NEOSTIGMINE | 4.0 | 1 | 8.34 |
| CHEMBL3221282 | — | — | 1 | 8.26 |
| CHEMBL2393224 | — | — | 1 | 8.18 |
| CHEMBL2393228 | — | — | 1 | 8.16 |
| CHEMBL3217792 | — | — | 1 | 8.15 |
| CHEMBL3221565 | — | — | 1 | 8.12 |
| CHEMBL2393225 | — | — | 1 | 8.10 |
| CHEMBL3221284 | — | — | 1 | 8.09 |
| CHEMBL3221287 | — | — | 1 | 8.07 |
| CHEMBL2393226 | — | — | 1 | 7.96 |
| CHEMBL2393106 | — | — | 1 | 7.87 |
| CHEMBL3221283 | — | — | 1 | 7.86 |
| CHEMBL3221569 | — | — | 1 | 7.77 |
| CHEMBL3221288 | — | — | 1 | 7.76 |
| CHEMBL3221278 | — | — | 1 | 7.74 |
| CHEMBL3221568 | — | — | 1 | 7.74 |
| CHEMBL3221289 | — | — | 1 | 7.73 |
| CHEMBL3221291 | — | — | 1 | 7.69 |
| CHEMBL3221290 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3221566 | — | IC50 | = | 0.418 | nM | 9.38 |
| CHEMBL2393227 | — | IC50 | = | 0.495 | nM | 9.30 |
| CHEMBL2393229 | — | IC50 | = | 0.776 | nM | 9.11 |
| CHEMBL2393109 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL3221006 | — | IC50 | = | 1.39 | nM | 8.86 |
| CHEMBL3221008 | — | IC50 | = | 1.54 | nM | 8.81 |
| CHEMBL3221292 | — | IC50 | = | 1.65 | nM | 8.78 |
| CHEMBL3221005 | — | IC50 | = | 2.24 | nM | 8.65 |
| CHEMBL2393111 | — | IC50 | = | 2.94 | nM | 8.53 |
| CHEMBL3221286 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3221285 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL278020 | NEOSTIGMINE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3221282 | — | IC50 | = | 5.55 | nM | 8.26 |
| CHEMBL2393224 | — | IC50 | = | 6.67 | nM | 8.18 |
| CHEMBL2393228 | — | IC50 | = | 6.94 | nM | 8.16 |
| CHEMBL3217792 | — | IC50 | = | 7.13 | nM | 8.15 |
| CHEMBL3221565 | — | IC50 | = | 7.65 | nM | 8.12 |
| CHEMBL2393225 | — | IC50 | = | 7.91 | nM | 8.10 |
| CHEMBL3221284 | — | IC50 | = | 8.09 | nM | 8.09 |
| CHEMBL3221287 | — | IC50 | = | 8.58 | nM | 8.07 |
| CHEMBL2393226 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL2393106 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL3221283 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL3221569 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3221288 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL3221278 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL3221568 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL3221289 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL3221291 | — | IC50 | = | 20.3 | nM | 7.69 |
| CHEMBL3221290 | — | IC50 | = | 28.1 | nM | 7.55 |
| CHEMBL2393107 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL3221567 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL2393110 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL3221010 | — | IC50 | = | 50.9 | nM | 7.29 |
| CHEMBL95 | TACRINE | IC50 | = | 52.4 | nM | 7.28 |
| CHEMBL3221007 | — | IC50 | = | 75.5 | nM | 7.12 |
| CHEMBL3221570 | — | IC50 | = | 80.1 | nM | 7.10 |
| CHEMBL1115 | PYRIDOSTIGMINE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3221270 | — | IC50 | = | 87.3 | nM | 7.06 |
| CHEMBL3221276 | — | IC50 | = | 89.7 | nM | 7.05 |
| CHEMBL3221293 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL3221280 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL3221274 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL3221009 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL3221275 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL3221273 | — | IC50 | = | 811.0 | nM | 6.09 |
| CHEMBL3221279 | — | IC50 | = | 985.0 | nM | 6.01 |
| CHEMBL2390978 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL3221281 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3221277 | — | IC50 | = | 1860.0 | nM | 5.73 |