Assay Detail
Binding
CHEMBL1065425
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Inhibition of human AChE by Ellman's method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.47 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL604478 | — | — | 1 | 7.80 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.68 |
| CHEMBL596236 | — | — | 1 | 7.66 |
| CHEMBL595114 | — | — | 1 | 7.62 |
| CHEMBL605303 | — | — | 1 | 7.60 |
| CHEMBL594187 | — | — | 1 | 7.60 |
| CHEMBL606348 | — | — | 1 | 7.54 |
| CHEMBL595115 | — | — | 1 | 7.51 |
| CHEMBL594870 | — | — | 1 | 7.51 |
| CHEMBL606538 | — | — | 1 | 7.51 |
| CHEMBL606372 | — | — | 1 | 7.40 |
| CHEMBL596457 | — | — | 1 | 7.39 |
| CHEMBL594186 | — | — | 1 | 7.29 |
| CHEMBL593933 | — | — | 1 | 7.08 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL604478 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL596236 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL595114 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL605303 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL594187 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL606348 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL595115 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL594870 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL606538 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL606372 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL596457 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL594186 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL593933 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL95 | TACRINE | IC50 | = | 128.0 | nM | 6.89 |