Assay Detail
Binding
CHEMBL1065705
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Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in CHO cells by liquid scintillation counting
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.17 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.92 |
| CHEMBL597094 | — | — | 1 | 8.51 |
| CHEMBL609317 | — | — | 1 | 8.17 |
| CHEMBL591916 | — | — | 1 | 7.96 |
| CHEMBL598037 | — | — | 1 | 7.92 |
| CHEMBL608728 | — | — | 1 | 7.92 |
| CHEMBL596885 | — | — | 1 | 7.85 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.70 |
| CHEMBL607559 | — | — | 1 | 7.54 |
| CHEMBL27559 | — | — | 1 | 7.35 |
| CHEMBL609611 | — | — | 1 | 7.34 |
| CHEMBL119455 | — | — | 1 | 7.31 |
| CHEMBL591448 | — | — | 1 | 7.26 |
| CHEMBL596886 | — | — | 1 | 7.18 |
| CHEMBL599065 | — | — | 1 | 7.05 |
| CHEMBL596678 | — | — | 1 | 6.90 |
| CHEMBL596884 | — | — | 1 | 6.87 |
| CHEMBL603752 | — | — | 1 | 6.84 |
| CHEMBL599080 | — | — | 1 | 6.83 |
| CHEMBL270426 | — | — | 1 | 6.59 |
| CHEMBL598759 | — | — | 1 | 6.55 |
| CHEMBL597881 | — | — | 1 | 6.50 |
| CHEMBL599064 | — | — | 1 | 6.47 |
| CHEMBL598760 | — | — | 1 | 6.43 |
| CHEMBL597882 | — | — | 1 | 6.29 |
| CHEMBL611973 | — | — | 1 | 6.20 |
| CHEMBL604588 | — | — | 1 | 6.20 |
| CHEMBL596865 | — | — | 1 | 6.10 |
| CHEMBL597095 | — | — | 1 | - |
| CHEMBL604179 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL597094 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL609317 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL591916 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL598037 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL608728 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL596885 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL49 | BUSPIRONE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL607559 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL27559 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL609611 | — | Ki | = | 45.3 | nM | 7.34 |
| CHEMBL119455 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL591448 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL596886 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL599065 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL596678 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL596884 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL603752 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL599080 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL270426 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL598759 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL597881 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL599064 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL598760 | — | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL597882 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL611973 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL604588 | — | Ki | = | 626.0 | nM | 6.20 |
| CHEMBL596865 | — | Ki | = | 793.0 | nM | 6.10 |
| CHEMBL597095 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL604179 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL596866 | — | Ki | - | — | - | |
| CHEMBL603542 | — | Ki | - | — | - |