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Assay Detail

CHEMBL1065706

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type HEK293
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(1A) dopamine receptor (CHEMBL2056)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.
Liu Z, Zhang H, Ye N, Zhang J, Wu Q, Sun P, Li L, Zhen X, Zhang A.
J Med Chem (2010) 53 : 1319 -1328
PubMed 20041669 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 7.28 7.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL270426 1 7.34
CHEMBL119455 1 7.21
CHEMBL609611 1 -
CHEMBL609317 1 -
CHEMBL603752 1 -
CHEMBL596886 1 -
CHEMBL607559 1 -
CHEMBL596885 1 -
CHEMBL596884 1 -
CHEMBL608728 1 -
CHEMBL597882 1 -
CHEMBL597881 1 -
CHEMBL597094 1 -
CHEMBL591448 1 -
CHEMBL603542 1 -
CHEMBL611973 1 -
CHEMBL596866 1 -
CHEMBL596865 1 -
CHEMBL599080 1 -
CHEMBL598760 1 -
CHEMBL598759 1 -
CHEMBL27559 1 -
CHEMBL596678 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL270426 Ki = 46.0 nM 7.34
CHEMBL119455 Ki = 61.0 nM 7.21
CHEMBL609611 Ki > 10000.0 nM -
CHEMBL609317 Ki > 10000.0 nM -
CHEMBL603752 Ki > 10000.0 nM -
CHEMBL596886 Ki > 10000.0 nM -
CHEMBL607559 Ki > 10000.0 nM -
CHEMBL596885 Ki > 10000.0 nM -
CHEMBL596884 Ki > 10000.0 nM -
CHEMBL608728 Ki > 10000.0 nM -
CHEMBL597882 Ki > 10000.0 nM -
CHEMBL597881 Ki > 10000.0 nM -
CHEMBL597094 Ki > 10000.0 nM -
CHEMBL591448 Ki > 10000.0 nM -
CHEMBL603542 Ki > 10000.0 nM -
CHEMBL611973 Ki > 10000.0 nM -
CHEMBL596866 Ki > 10000.0 nM -
CHEMBL596865 Ki > 10000.0 nM -
CHEMBL599080 Ki > 10000.0 nM -
CHEMBL598760 Ki > 10000.0 nM -
CHEMBL598759 Ki > 10000.0 nM -
CHEMBL27559 Ki > 10000.0 nM -
CHEMBL596678 Ki > 10000.0 nM -