Assay Detail
Functional
CHEMBL1065709
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Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.98 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608728 | — | — | 1 | 7.25 |
| CHEMBL597094 | — | — | 1 | 7.07 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.83 |
| CHEMBL596885 | — | — | 1 | 6.75 |
| CHEMBL609317 | — | — | 1 | - |
| CHEMBL609611 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608728 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL597094 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL39 | SEROTONIN | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL596885 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL609317 | — | EC50 | - | — | - | |
| CHEMBL609611 | — | EC50 | - | — | - |