Assay Detail
Functional
CHEMBL1065711
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Agonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma binding
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.91 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609611 | — | — | 1 | 7.75 |
| CHEMBL608728 | — | — | 1 | 6.49 |
| CHEMBL609317 | — | — | 1 | 6.49 |
| CHEMBL597094 | — | — | 1 | - |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609611 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL608728 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL609317 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL597094 | — | IC50 | - | — | - | |
| CHEMBL39 | SEROTONIN | IC50 | - | — | - |