Assay Detail
Binding
CHEMBL1065857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX2 in mouse RAW264.7 cells by enzyme immunoassay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.72 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95311 | — | — | 1 | 6.68 |
| CHEMBL7162 | NS-398 | — | 1 | 6.09 |
| CHEMBL605161 | — | — | 1 | 5.36 |
| CHEMBL602247 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95311 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL7162 | NS-398 | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL605161 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL602247 | — | IC50 | = | 18100.0 | nM | 4.74 |