Assay Detail
Functional
CHEMBL1066261
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Cytotoxicity against human HL60 cells after 48 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel semisynthetic spin-labeled derivatives of podophyllotoxin with cytotoxic and antioxidative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.56 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592174 | — | — | 1 | 6.80 |
| CHEMBL592178 | — | — | 1 | 6.68 |
| CHEMBL592397 | — | — | 1 | 6.68 |
| CHEMBL592321 | — | — | 1 | 6.66 |
| CHEMBL592396 | — | — | 1 | 6.62 |
| CHEMBL592354 | — | — | 1 | 6.50 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.38 |
| CHEMBL578298 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592174 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL592178 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL592397 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL592321 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL592396 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL592354 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL578298 | — | IC50 | = | 670.0 | nM | 6.17 |