Assay Detail
Functional
CHEMBL1066299
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Antineuroinflammatory activity in LPS-stimulated rat neonatal microglia assessed as inhibition of PMA-induced superoxide anion production preincubated 15 mins prior to PMA challenge measured after 70 mins
20
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Microglia |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.10 | 7.52 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL579148 | — | — | 1 | 7.52 |
| CHEMBL578331 | 9-N-NEOPENTYLMANZAMINE A | — | 1 | 7.16 |
| CHEMBL403233 | MANZAMINE A | — | 1 | 7.00 |
| CHEMBL578532 | 6-METHOXYMANZAMINE A | — | 1 | 7.00 |
| CHEMBL592429 | 9-N-BUTYLMANZAMINE A | — | 1 | 6.92 |
| CHEMBL578914 | — | — | 1 | 5.66 |
| CHEMBL592631 | MANZAMINE D | — | 1 | 5.61 |
| CHEMBL592610 | 9-N-PROPYLMANZAMINE A | — | 1 | 5.52 |
| CHEMBL578725 | 9-N-ISOPENTYLMANZAMINE A | — | 1 | 5.50 |
| CHEMBL578116 | 9-N-ISOBUTYLMANZAMINE A | — | 1 | 5.24 |
| CHEMBL579152 | — | — | 1 | 5.07 |
| CHEMBL592629 | 9-N-ETHYLMANZAMINE A | — | 1 | 5.01 |
| CHEMBL332054 | IRCINAL | — | 1 | - |
| CHEMBL578745 | — | — | 1 | - |
| CHEMBL437596 | TETRAHYDROMANZAMINE A | — | 2 | - |
| CHEMBL592237 | 9-N-METHYLMANZAMINE A | — | 1 | - |
| CHEMBL612054 | — | — | 1 | - |
| CHEMBL443503 | 15,16,32,33-TETRAHYDRO-8-HYDROXYMANZAMINE A | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL579148 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL578331 | 9-N-NEOPENTYLMANZAMINE A | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL403233 | MANZAMINE A | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL578532 | 6-METHOXYMANZAMINE A | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL592429 | 9-N-BUTYLMANZAMINE A | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL578914 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL592631 | MANZAMINE D | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL592610 | 9-N-PROPYLMANZAMINE A | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL578725 | 9-N-ISOPENTYLMANZAMINE A | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL578116 | 9-N-ISOBUTYLMANZAMINE A | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL579152 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL592629 | 9-N-ETHYLMANZAMINE A | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL437596 | TETRAHYDROMANZAMINE A | IC50 | > | 10000.0 | nM | - |
| CHEMBL612054 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL592237 | 9-N-METHYLMANZAMINE A | IC50 | > | 10000.0 | nM | - |
| CHEMBL443503 | 15,16,32,33-TETRAHYDRO-8-HYDROXYMANZAMINE A | Activity | - | — | - | |
| CHEMBL443503 | 15,16,32,33-TETRAHYDRO-8-HYDROXYMANZAMINE A | IC50 | > | 10000.0 | nM | - |
| CHEMBL578745 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL332054 | IRCINAL | IC50 | > | 10000.0 | nM | - |
| CHEMBL437596 | TETRAHYDROMANZAMINE A | Activity | - | — | - |