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Assay Detail

CHEMBL1066432

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive-type inhibition of autotaxin-mediated FS3 hydrolysis by Michaelis-Menten analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Autotaxin (CHEMBL3691)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Characterization of non-lipid autotaxin inhibitors.
Hoeglund AB, Howard AL, Wanjala IW, Pham TC, Parrill AL, Baker DL.
Bioorg Med Chem (2010) 18 : 769 -776
PubMed 20005724 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 5.51 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL268789 1 5.72
CHEMBL442472 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL268789 Ki = 1900.0 nM 5.72
CHEMBL442472 Ki = 5000.0 nM 5.30