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Assay Detail

CHEMBL1066771

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at 5HT2C receptor in rat fundus
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2C (CHEMBL324)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.
Ahmad S, Ngu K, Miller KJ, Wu G, Hung CP, Malmstrom S, Zhang G, O'Tanyi E, Keim WJ, Cullen MJ, Rohrbach KW, Thomas M, Ung T, Qu Q, Gan J, Narayanan R, Pelleymounter MA, Robl JA.
Bioorg Med Chem Lett (2010) 20 : 1128 -1133
PubMed 20022752 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 7.21 7.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL590580 1 7.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL590580 EC50 = 61.0 nM 7.21