Assay Detail
Binding
CHEMBL1067130
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Inhibition of human recombinant AChE preincubated for 20 mins before substrate addition by Ellman's method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.20 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.70 |
| CHEMBL75121 | — | — | 1 | 7.36 |
| CHEMBL599644 | — | — | 1 | 7.28 |
| CHEMBL597188 | — | — | 1 | 7.25 |
| CHEMBL597794 | — | — | 1 | 6.96 |
| CHEMBL597822 | — | — | 1 | 6.75 |
| CHEMBL604096 | — | — | 1 | 6.75 |
| CHEMBL599057 | — | — | 1 | 6.72 |
| CHEMBL603256 | — | — | 1 | 6.70 |
| CHEMBL599058 | — | — | 1 | 6.42 |
| CHEMBL598824 | — | — | 1 | 6.29 |
| CHEMBL610779 | — | — | 1 | 6.20 |
| CHEMBL598645 | — | — | 1 | 6.05 |
| CHEMBL597821 | — | — | 1 | 6.05 |
| CHEMBL598632 | — | — | 1 | 5.94 |
| CHEMBL599254 | — | — | 1 | 5.88 |
| CHEMBL599253 | — | — | 1 | 5.82 |
| CHEMBL597001 | — | — | 1 | 5.79 |
| CHEMBL604715 | — | — | 1 | 5.54 |
| CHEMBL599252 | — | — | 1 | 5.40 |
| CHEMBL597405 | — | — | 1 | 5.31 |
| CHEMBL597795 | — | — | 1 | 5.27 |
| CHEMBL597406 | — | — | 1 | 4.93 |
| CHEMBL610219 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL75121 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL599644 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL597188 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL597794 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL597822 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL604096 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL599057 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL603256 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL599058 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL598824 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL610779 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL598645 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL597821 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL598632 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL599254 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL599253 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL597001 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL604715 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL599252 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL597405 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL597795 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL597406 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL610219 | — | IC50 | = | 28700.0 | nM | 4.54 |